Article
Integrated genomic study of quadruple-WT GIST (KIT/PDGFRA/SDH/RAS pathway wild-type GIST).
BMC cancer - 20 Sept 2014
Nannini Margherita, Astolfi Annalisa, Urbini Milena, Indio Valentina, Santini Donatella, Heinrich Michael C, Corless Christopher L, Ceccarelli Claudio, Saponara Maristella, Mandrioli Anna, Lolli Cristian, Ercolani Giorgio, Brandi Giovanni, Biasco Guido, Pantaleo Maria A
Abstract excerpt
BACKGROUND: About 10-15% of adult gastrointestinal stromal tumors (GIST) and the vast majority of pediatric GIST do not harbour KIT or platelet-derived growth factor receptor alpha (PDGFRA) mutations (J Clin Oncol 22:3813-3825, 2004; Hematol Oncol Clin North Am 23:15-34, 2009). The molecular biology of these GIST, originally defined as KIT/PDGFRA wild-type (WT), is complex due to the existence of different...
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