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Article

Integrated genomic analyses identify frequent gene fusion events and VHL inactivation in gastrointestinal stromal tumors.

Oncotarget - 9 Feb 2016

Kang Guhyun, Yun Hongseok, Sun Choong-Hyun, Park Inho, Lee Seungmook, Kwon Jekeun, Do Ingu, Hong Min Eui, Van Vrancken Michael, Lee Jeeyun, Park Joon Oh, Cho Jeonghee, Kim Kyoung-Mee, Sohn Tae Sung

Abstract excerpt

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. We sequenced nine exomes and transcriptomes, and two genomes of GISTs for integrated analyses. We detected 306 somatic variants in nine GISTs and recurrent protein-altering mutations in 29 genes. Transcriptome sequencing revealed 328 gene fusions, and the most frequently involved fusion events were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gastrointestinal Neoplasms

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Share to Gene Expression Regulation, Neoplastic

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Source

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Identifiers

PMID: 25987131
DOI: 10.18632/oncotarget.3731
PMCID: PMC4872731

Genes

VHL
AMACR
CCND1
CRIM1
FBXO25
FUS
IGF2
LASP1
NPEPL1
POLA2
SKP2
STX16

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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