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Article

FGFR1 and NTRK3 actionable alterations in "Wild-Type" gastrointestinal stromal tumors.

Journal of translational medicine - 14 Dec 2016

Shi Eileen, Chmielecki Juliann, Tang Chih-Min, Wang Kai, Heinrich Michael C, Kang Guhyun, Corless Christopher L, Hong David, Fero Katherine E, Murphy James D, Fanta Paul T, Ali Siraj M, De Siena Martina, Burgoyne Adam M, Movva Sujana, Madlensky Lisa, Heestand Gregory M, Trent Jonathan C, Kurzrock Razelle, Morosini Deborah, Ross Jeffrey S, Harismendy Olivier, Sicklick Jason K

Abstract excerpt

BACKGROUND: About 10-15% of adult, and most pediatric, gastrointestinal stromal tumors (GIST) lack mutations in KIT, PDGFRA, SDHx, or RAS pathway components (KRAS, BRAF, NF1). The identification of additional mutated genes in this rare subset of tumors can have important clinical benefit to identify altered biological pathways and select targeted therapies. METHODS: We performed comprehensive genomic profiling...

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Topics

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Share to Demography
Share to Gastrointestinal Stromal Tumors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to NTRK3 gene

Share to Genome, Human

Share to Mutation

Share to Oncogene Proteins, Fusion

Share to Receptor, Fibroblast Growth Factor, Type 1

Share to Receptor, trkC

Source

Open in PubMed Open full text

Identifiers

PMID: 27974047
DOI: 10.1186/s12967-016-1075-6
PMCID: PMC5157084

Genes

FGFR1
NTRK3
KIT
PDGFRA
ETV6
TACC1
ATR
BRAF
HOOK3
KRAS
LTK
SUFU

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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