Article
Transcriptome sequencing identifies ETV6-NTRK3 as a gene fusion involved in GIST.
The Journal of pathology - 1 Mar 2016
Brenca Monica, Rossi Sabrina, Polano Maurizio, Gasparotto Daniela, Zanatta Lucia, Racanelli Dominga, Valori Laura, Lamon Stefano, Dei Tos Angelo Paolo, Maestro Roberta
Abstract excerpt
Gastrointestinal stromal tumours (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract. The vast majority of GISTs are driven by oncogenic activation of KIT, PDGFRA or, less commonly, BRAF. Loss of succinate dehydrogenase complex activity has been identified in subsets of KIT/PDGFRA/BRAF-mutation negative tumours, yet a significant fraction of GISTs are devoid of any of such alterations....
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