Article
Quadruple-Negative GIST Is a Sentinel for Unrecognized Neurofibromatosis Type 1 Syndrome.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jan 2017
Gasparotto Daniela, Rossi Sabrina, Polano Maurizio, Tamborini Elena, Lorenzetto Erica, Sbaraglia Marta, Mondello Alessia, Massani Marco, Lamon Stefano, Bracci Raffaella, Mandolesi Alessandra, Frate Elisabetta, Stanzial Franco, Agaj Jerin, Mazzoleni Guido, Pilotti Silvana, Gronchi Alessandro, Dei Tos Angelo Paolo, Maestro Roberta
Abstract excerpt
PURPOSE: The majority of gastrointestinal stromal tumors (GIST) are driven by KIT, PDGFRA, or, less commonly, BRAF mutations, and SDH gene inactivation is involved in a limited fraction of gastric lesions. However, about 10% of GISTs are devoid of any of such alterations and are poorly responsive to standard treatments. This study aims to shed light on the molecular drivers of quadruple-negative GISTs....
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