Article
Genetics of Cd36 and the clustering of multiple cardiovascular risk factors in spontaneous hypertension.
The Journal of clinical investigation - 1 Jun 1999
Pravenec M, Zidek V, Simakova M, Kren V, Krenova D, Horky K, Jachymova M, Mikova B, Kazdova L, Aitman T J, Churchill P C, Webb R C, Hingarh N H, Yang Y, Wang J M, Lezin E M, Kurtz T W
Abstract excerpt
Disorders of carbohydrate and lipid metabolism have been reported to cluster in patients with essential hypertension and in spontaneously hypertensive rats (SHRs). A deletion in the Cd36 gene on chromosome 4 has recently been implicated in defective carbohydrate and lipid metabolism in isolated adipocytes from SHRs. However, the role of Cd36 and chromosome 4 in the control of blood pressure and systemic...
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