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Article

HS3ST1 genotype regulates antithrombin's inflammomodulatory tone and associates with atherosclerosis.

Matrix biology : journal of the International Society for Matrix Biology - 1 Nov 2017

Smits Nicole C, Kobayashi Takashi, Srivastava Pratyaksh K, Skopelja Sladjana, Ivy Julianne A, Elwood Dustin J, Stan Radu V, Tsongalis Gregory J, Sellke Frank W, Gross Peter L, Cole Michael D, DeVries James T, Kaplan Aaron V, Robb John F, Williams Scott M, Shworak Nicholas W

Abstract excerpt

The HS3ST1 gene controls endothelial cell production of HSAT+ - a form of heparan sulfate containing a specific pentasaccharide motif that binds the anticoagulant protein antithrombin (AT). HSAT+ has long been thought to act as an endogenous anticoagulant; however, coagulation was normal in Hs3st1-/- mice that have greatly reduced HSAT+ (HajMohammadi et al., 2003). This finding indicates that HSAT+ is not...

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PMID: 28126521
DOI: 10.1016/j.matbio.2017.01.003
PMCID: PMC5532081

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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