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Article

The Genetic Landscape of Plasma P-Selectin Glycoprotein Ligand Levels and Bidirectional Mendelian Randomization to Assess Role in Proinflammatory Cytokine Levels.

Genes - 16 Jul 2026

Bime Christian, Klimentidis Yann C, Sun Xiaoguang, Floyd Chilton H, Standage-Beier Carrie S, Saad Sammani, Casanova Nancy G, Hufford Mathew K, Camp Sara M, Garcia Joe G N

Abstract excerpt

BACKGROUND: Polymorphonuclear (PMN) leukocyte recruitment to activated pulmonary endothelium is a central mechanism in acute respiratory distress syndrome (ARDS). This process is mediated by selectins and their counter-ligand, P-selectin glycoprotein ligand-1 (PSGL-1), encoded by SELPLG. Genetic variation in SELPLG has been associated with ARDS susceptibility, while disruption of PSGL-1/P-selectin interactions...

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Source

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Identifiers

PMID: 42510851
DOI: 10.3390/genes17070811
PMCID: PMC13409549

Genes

SELPLG
CRP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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