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Article

Biased agonism of protease-activated receptor-1 regulates thromboinflammation in murine sickle cell disease

19 Apr 2024

Abstract excerpt

ABSTRACT: Sickle cell disease (SCD) is a hereditary hemoglobinopathy marked by hemolytic anemia and vaso-occlusive events (VOEs). Chronic endothelial activation, inflammation, and coagulation activation contribute to vascular congestion, VOEs, and end-organ damage. Coagulation proteases such as thrombin and activated protein C (APC) modulate inflammation and endothelial dysfunction by activating...

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PMID: 38640339
DOI: 10.1182/bloodadvances.2023011907

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