Article
The single nucleotide polymorphism Ser128Arg in the E-selectin gene is associated with enhanced coagulation during human endotoxemia.
Blood - 15 Mar 2005
Jilma Bernd, Marsik Claudia, Kovar Florian, Wagner Oswald F, Jilma-Stohlawetz Petra, Endler Georg
Abstract excerpt
The single nucleotide polymorphism (SNP) Ser128Arg in the E-selectin gene is overrepresented in certain patient groups with atherosclerosis or restenosis. We hypothesized and tested whether it may affect cytokine-induced levels of soluble (s) E-selectin, or be associated with proinflammatory or p...
Topics
- Amino Acid Substitution
- Blood Coagulation
- Cytokines
- E-Selectin
- Endotoxemia
- Enzyme-Linked Immunosorbent Assay
- Fibrin Fibrinogen Degradation Products
- Genetic Linkage
- Genotype
- Humans
- Leukocyte Count
- Lipopolysaccharides
- Male
- Polymorphism, Single Nucleotide
- Reverse Transcriptase Polymerase Chain Reaction
- Thrombin
- Thrombosis