Loss of Sirt3 accelerates arterial thrombosis by increasing formation of neutrophil extracellular traps and plasma tissue factor activity.

doi:10.1093/cvr/cvy036

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Article

Loss of Sirt3 accelerates arterial thrombosis by increasing formation of neutrophil extracellular traps and plasma tissue factor activity.

Cardiovascular research - 1 Jul 2018

Gaul Daniel S, Weber Julien, van Tits Lambertus J, Sluka Susanna, Pasterk Lisa, Reiner Martin F, Calatayud Natacha, Lohmann Christine, Klingenberg Roland, Pahla Jürgen, Vdovenko Daria, Tanner Felix C, Camici Giovanni G, Eriksson Urs, Auwerx Johan, Mach François, Windecker Stephan, Rodondi Nicolas, Lüscher Thomas F, Winnik Stephan, Matter Christian M

Abstract excerpt

Aims: Sirtuin 3 (Sirt3) is a mitochondrial, nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase that reduces oxidative stress by activation of superoxide dismutase 2 (SOD2). Oxidative stress enhances arterial thrombosis. This study investigated the effects of genetic Sirt3 deletion on arterial thrombosis in mice in an inflammatory setting and assessed the clinical relevance of these findings in...

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Identifiers

PMID: 29444200
DOI: 10.1093/cvr/cvy036
PMCID: PMC6014146

Genes

SOD2
SIRT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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