Article

The Genetic Landscape of Plasma P-Selectin Glycoprotein Ligand levels and Bidirectional Mendelian Randomization to Assess Role in Proinflammatory Cytokine levels

2026-06-18

Abstract excerpt

<h4>Background: </h4> Polymorphonuclear (PMN) leukocyte recruitment to activated pulmonary endothelium is a central mechanism in acute respiratory distress syndrome (ARDS). This process is mediated by selectins and their counter-ligand, P-selectin glycoprotein ligand-1 (PSGL-1), encoded by SELPLG. Genetic variation in SELPLG has been associated with ARDS susceptibility, while disruption of PSGL-1/P-selectin intera...

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Literature Corpus work: 71a36340-4f3e-571c-a6cf-d551e1196add
DOI: 10.20944/preprints202606.1396.v1

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