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Article

Expression and functional characterization of two natural heparin-binding site variants of antithrombin.

Journal of thrombosis and haemostasis : JTH - 1 Feb 2018

Dinarvand P, Yang L, Villoutreix B O, Rezaie A R

Abstract excerpt

Essentials Heparin-binding site (HBS) variants of antithrombin (AT) are associated with thrombosis risk. HSB variants have, in general, normal progressive inhibitory activity but reduced heparin affinity. Thrombosis in HSB carriers has been primarily attributed to the loss of heparin cofactor activity. Results here demonstrate that HSB variants of AT also lack anti-inflammatory signaling functions. SUMMARY:...

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Identifiers

PMID: 29215785
DOI: 10.1111/jth.13920
PMCID: PMC5809256

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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