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Article

Normal levels of anticoagulant heparan sulfate are not essential for normal hemostasis.

The Journal of clinical investigation - 1 Apr 2003

HajMohammadi Sassan, Enjyoji Keiichi, Princivalle Marc, Christi Patricia, Lech Miroslav, Beeler David, Rayburn Helen, Schwartz John J, Barzegar Samad, de Agostini Ariane I, Post Mark J, Rosenberg Robert D, Shworak Nicholas W

Abstract excerpt

Endothelial cell production of anticoagulant heparan sulfate (HS(act)) is controlled by the Hs3st1 gene, which encodes the rate-limiting enzyme heparan sulfate 3-O-sulfotransferase-1 (3-OST-1). In vitro, HS(act) dramatically enhances the neutralization of coagulation proteases by antithrombin. The in vivo role of HS(act) was evaluated by generating Hs3st1(-/-) knockout mice. Hs3st1(-/-) animals were devoid of...

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Identifiers

PMID: 12671048
DOI: 10.1172/JCI15809
PMCID: PMC152578

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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