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In the balance: how do thrombospondins contribute to the cellular pathophysiology of cardiovascular disease?

8 Sept 2021

Abstract excerpt

Thrombospondins (TSPs) are multidomain, secreted proteins that associate with cell surfaces and extracellular matrix. In mammals, there is a large body of data on functional roles of various TSP family members in cardiovascular disease (CVD), including stroke, cardiac remodeling and fibrosis, atherosclerosis, and aortic aneurysms. Coding single nucleotide polymorphisms (SNPs) of TSP1 or TSP4 are also associated...

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PMID: 34495764
DOI: 10.1152/ajpcell.00251.2021

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