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Article

MEDICI: Mining Essentiality Data to Identify Critical Interactions for Cancer Drug Target Discovery and Development.

PloS one - 1 Jan 2017

Harati Sahar, Cooper Lee A D, Moran Josue D, Giuste Felipe O, Du Yuhong, Ivanov Andrei A, Johns Margaret A, Khuri Fadlo R, Fu Haian, Moreno Carlos S

Abstract excerpt

Protein-protein interactions (PPIs) mediate the transmission and regulation of oncogenic signals that are essential to cellular proliferation and survival, and thus represent potential targets for anti-cancer therapeutic discovery. Despite their significance, there is no method to experimentally disrupt and interrogate the essentiality of individual endogenous PPIs. The ability to computationally predict or infer...

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Identifiers

PMID: 28118365
DOI: 10.1371/journal.pone.0170339
PMCID: PMC5261804

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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