Article
Controllability analysis of the directed human protein interaction network identifies disease genes and drug targets.
Proceedings of the National Academy of Sciences of the United States of America - 3 May 2016
Vinayagam Arunachalam, Gibson Travis E, Lee Ho-Joon, Yilmazel Bahar, Roesel Charles, Hu Yanhui, Kwon Young, Sharma Amitabh, Liu Yang-Yu, Perrimon Norbert, Barabási Albert-László
Abstract excerpt
The protein-protein interaction (PPI) network is crucial for cellular information processing and decision-making. With suitable inputs, PPI networks drive the cells to diverse functional outcomes such as cell proliferation or cell death. Here, we characterize the structural controllability of a large directed human PPI network comprising 6,339 proteins and 34,813 interactions. This network allows us to classify...
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