Article

Biological network topology features predict gene dependencies in cancer cell lines

2019-08-31

Abstract excerpt

In this paper we explore computational approaches that enable us to identify genes that have become essential in individual cancer cell lines. Using recently published experimental cancer cell line gene essentiality data, human protein-protein interaction (PPI) network data and individual cell-line genomic alteration data we have built a range of machine learning classification models to predict cell line specific...

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Literature Corpus work: e10e6d15-6091-53ac-8655-20997f60989d
DOI: 10.1101/751776

Open publication

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