Article
Characterizing protein interactions employing a genome-wide siRNA cellular phenotyping screen.
PLoS computational biology - 1 Sept 2014
Suratanee Apichat, Schaefer Martin H, Betts Matthew J, Soons Zita, Mannsperger Heiko, Harder Nathalie, Oswald Marcus, Gipp Markus, Ramminger Ellen, Marcus Guillermo, Männer Reinhard, Rohr Karl, Wanker Erich, Russell Robert B, Andrade-Navarro Miguel A, Eils Roland, König Rainer
Abstract excerpt
Characterizing the activating and inhibiting effect of protein-protein interactions (PPI) is fundamental to gain insight into the complex signaling system of a human cell. A plethora of methods has been suggested to infer PPI from data on a large scale, but none of them is able to characterize the effect of this interaction. Here, we present a novel computational development that employs mitotic phenotypes of a...
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