Article

Mechanism-aware inference of response to targeted cancer therapies

2025-09-09

Abstract excerpt

Targeted therapies like small-molecule inhibitors often work by blocking proteins that cancer cells rely on for survival. Omics based modeling of drug sensitivity alone lack mechanistic grounding. We propose FORGE (Factorization Of Response and Gene Essentiality) a simple yet powerful joint matrix factorization framework that co-models drug response and target gene essentiality, enabling the stratification of prom...

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Literature Corpus work: 4801b379-7ca8-5412-b16c-cde3a1f90bcb
DOI: 10.1101/2025.09.04.674143

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