Article
Oncoprotein-specific molecular interaction maps (SigMaps) for cancer network analyses.
Nature biotechnology - 1 Feb 2021
Broyde Joshua, Simpson David R, Murray Diana, Paull Evan O, Chu Brennan W, Tagore Somnath, Jones Sunny J, Griffin Aaron T, Giorgi Federico M, Lachmann Alexander, Jackson Peter, Sweet-Cordero E Alejandro, Honig Barry, Califano Andrea
Abstract excerpt
Tumor-specific elucidation of physical and functional oncoprotein interactions could improve tumorigenic mechanism characterization and therapeutic response prediction. Current interaction models and pathways, however, lack context specificity and are not oncoprotein specific. We introduce SigMaps as context-specific networks, comprising modulators, effectors and cognate binding-partners of a specific...
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