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Article

Akt3 is a privileged first responder in isozyme-specific electrophile response.

Nature chemical biology - 1 Mar 2017

Long Marcus J C, Parvez Saba, Zhao Yi, Surya Sanjna L, Wang Yiran, Zhang Sheng, Aye Yimon

Abstract excerpt

Isozyme-specific post-translational regulation fine tunes signaling events. However, redundancy in sequence or activity renders links between isozyme-specific modifications and downstream functions uncertain. Methods to study this phenomenon are underdeveloped. Here we use a redox-targeting screen to reveal that Akt3 is a first-responding isozyme sensing native electrophilic lipids. Electrophile modification of...

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Identifiers

PMID: 28114274
DOI: 10.1038/nchembio.2284
PMCID: PMC5586141

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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