Article

ABHD11 regulates 2-oxoglutarate abundance by protecting mitochondrial lipoylated proteins from lipid peroxidation damage

2020-04-18

Abstract excerpt

2-oxoglutarate (2-OG or α-ketoglutarate) relates mitochondrial metabolism to cell function by modulating the activity of 2-OG dependent dioxygenases (2-OG DDs) involved in the hypoxia response and DNA/histone modifications. However, metabolic pathways that regulate these oxygen and 2-OG sensitive enzymes remain poorly understood. Here, using CRISPR Cas9 genome-wide mutagenesis to screen for genetic determinants of...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e3589d9e-8896-5d44-8609-c2e2a9eed106
DOI: 10.1101/2020.04.18.048082

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

ABHD11 regulates 2-oxoglutarate abundance by protecting mitochondrial lipoylated proteins from lipid peroxidation damageDOI 10.1101/2020.04.18.048082Read

Metabolic Rewiring in the Face of Genomic Assault: Integrating DNA Damage Response and Cellular MetabolismSemantic proximity Read

ALKBH7 mediates necrosis via rewiring of glyoxal metabolismSemantic proximity Read

Roles Of HIF and 2-Oxoglutarate Dependent Enzymes in Controlling Gene Expression In HypoxiaSemantic proximity Read

The Role of 2-Oxoglutarate Dependent Dioxygenases in Gliomas and Glioblastomas: A Review of Epigenetic Reprogramming and Hypoxic ResponseSemantic proximity Read

Glutathionylation of Pyruvate Dehydrogenase Complex E2 and Inflammatory Cytokine Production During Acute Inflammation Are Magnified By Mitochondrial Oxidative StressSemantic proximity Read

Metabolic Coordination of Cell Fate by α-Ketoglutarate-Dependent Dioxygenases.Semantic proximity Read

Beyond Isocitrate Dehydrogenase Mutations: Emerging Mechanisms for the Accumulation of the Oncometabolite 2-Hydroxyglutarate.Semantic proximity Read

A genetically encoded tool to increase cellular NADH/NAD <sup>+</sup> ratio in living cellsSemantic proximity Read

ALDH9A1 Deficiency as a Source of Endogenous DNA Damage that Requires Repair by the Fanconi Anemia PathwaySemantic proximity Read

The transaminase-ω-amidase pathway is a redox switch in glutamine metabolism that generates α-ketoglutarateSemantic proximity Read

Succinylation and redox status in cancer cellsSemantic proximity Read

Acetaldehyde dehydrogenase 2 deficiency increases mitochondrial reactive oxygen species emission and induces mitochondrial protease Omi/HtrA2 in skeletal muscle.Semantic proximity Read