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Article

Rapid Phenotypic Screening of Lysine-Degrading Probiotics via FTIR Spectroscopy: Toward Precision Therapy for Hyperlysinemia.

ACS synthetic biology - 20 Feb 2026

Zhang Yiqing, Wu Mingyu, Li Xueling, Geng Feng, Lü Junhong, Wang Yadi

Abstract excerpt

Hyperlysinemia is a life-threatening metabolic disorder that requires the continuous clearance of lysine. Engineered probiotics capable of degrading lysine in the gut represent a promising therapeutic strategy. However, the introduction of heterologous metabolic pathways can impose a substantial fitness burden on the bacterial host, potentially compromising the therapeutic efficacy. Current screening methods fail...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 41521607
DOI: 10.1021/acssynbio.5c00725

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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