Article

A novel redox-active switch in Fructosamine-3-kinases expands the regulatory repertoire of the protein kinase superfamily

2020-01-14

Abstract excerpt

Aberrant regulation of metabolic kinases by altered redox homeostasis is a major contributing factor in aging and disease such as diabetes. However, the biochemical mechanisms by which metabolic kinases are regulated under oxidative stress is poorly understood. In this study, we demonstrate that the catalytic activity of a conserved family of Fructosamine-3-kinases (FN3Ks), which are evolutionarily related to euka...

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Literature Corpus work: a17d4b71-0b89-5da3-8b15-2b50f3fdc9e2
DOI: 10.1101/2020.01.13.904870

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