Article
A genetic screen for high copy number suppressors of the synthetic lethality between elg1Δ and srs2Δ in yeast.
G3 (Bethesda, Md.) - 20 May 2013
Gazy Inbal, Liefshitz Batia, Bronstein Alex, Parnas Oren, Atias Nir, Sharan Roded, Kupiec Martin
Abstract excerpt
Elg1 and Srs2 are two proteins involved in maintaining genome stability in yeast. After DNA damage, the homotrimeric clamp PCNA, which provides stability and processivity to DNA polymerases and serves as a docking platform for DNA repair enzymes, undergoes modification by the ubiquitin-like molecule SUMO. PCNA SUMOylation helps recruit Srs2 and Elg1 to the replication fork. In the absence of Elg1, both SUMOylated...
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