Article
Rapid generation of hypomorphic mutations.
Nature communications - 20 Jan 2017
Arthur Laura L, Chung Joyce J, Jankirama Preetam, Keefer Kathryn M, Kolotilin Igor, Pavlovic-Djuranovic Slavica, Chalker Douglas L, Grbic Vojislava, Green Rachel, Menassa Rima, True Heather L, Skeath James B, Djuranovic Sergej
Abstract excerpt
Hypomorphic mutations are a valuable tool for both genetic analysis of gene function and for synthetic biology applications. However, current methods to generate hypomorphic mutations are limited to a specific organism, change gene expression unpredictably, or depend on changes in spatial-temporal expression of the targeted gene. Here we present a simple and predictable method to generate hypomorphic mutations in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.