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Article

Efficient allelic-drive in Drosophila.

Nature communications - 9 Apr 2019

Guichard Annabel, Haque Tisha, Bobik Marketta, Xu Xiang-Ru S, Klanseck Carissa, Kushwah Raja Babu Singh, Berni Mateus, Kaduskar Bhagyashree, Gantz Valentino M, Bier Ethan

Abstract excerpt

Gene-drive systems developed in several organisms result in super-Mendelian inheritance of transgenic insertions. Here, we generalize this "active genetic" approach to preferentially transmit allelic variants (allelic-drive) resulting from only a single or a few nucleotide alterations. We test two configurations for allelic-drive: one, copy-cutting, in which a non-preferred allele is selectively targeted for...

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Identifiers

PMID: 30967548
DOI: 10.1038/s41467-019-09694-w
PMCID: PMC6456580

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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