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Article

Clonal evolution in therapy-related neoplasms.

Oncotarget - 14 Feb 2017

Fabiani Emiliano, Falconi Giulia, Fianchi Luana, Criscuolo Marianna, Ottone Tiziana, Cicconi Laura, Hohaus Stefan, Sica Simona, Postorino Massimiliano, Neri Antonino, Lionetti Marta, Leone Giuseppe, Lo-Coco Francesco, Voso Maria Teresa

Abstract excerpt

Therapy-related myeloid neoplasms (t-MN) may occur as a late effect of cytotoxic therapy for a primary malignancy or autoimmune diseases in susceptible individuals. We studied the development of somatic mutations in t-MN, using a collection of follow-up samples from 14 patients with a primary hematologic malignancy, who developed a secondary leukemia (13 t-MN and 1 t-acute lymphoblastic leukemia), at a median...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28076841
DOI: 10.18632/oncotarget.14509
PMCID: PMC5355323

Genes

ASXL1
AFF1
IDH1
SETBP1
SRSF2

Variants

Provenance

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