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Article

Clonal evolution in patients developing therapy-related myeloid neoplasms following autologous stem cell transplantation.

Bone marrow transplantation - 1 Mar 2022

Soerensen Johannes Frasez, Aggerholm Anni, Rosenberg Carina Agerbo, Bill Marie, Kerndrup Gitte Birk, Ebbesen Lene Hyldahl, Hansen Marcus Høy, Roug Anne Stidsholt, Ludvigsen Maja

Abstract excerpt

Clonal hematopoiesis (CH) denotes somatic mutations in genes related to myeloid neoplasms present at any variant allele frequency (VAF). Clonal hematopoiesis is associated with increasing age and with a factor 6 increase in the risk of developing therapy-related myeloid neoplasms (tMNs) following autologous stem cell transplantation (ASCT). However, the impact of specific mutations on progression from CH to tMN...

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Share to Acute Myeloid Leukemia Research
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35027675
DOI: 10.1038/s41409-022-01567-z

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