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Article

The role of clonal hematopoiesis as driver of therapy-related myeloid neoplasms after autologous stem cell transplantation.

Annals of hematology - 1 Jun 2022

Gramegna Doriana, Bertoli Diego, Cattaneo Chiara, Almici Camillo, Re Alessandro, Belotti Angelo, Borlenghi Erika, Lanzi Gaetana, Archetti Silvana, Verardi Rosanna, Brugnoni Duilio, Sciumè Margherita, Daffini Rosa, Roccaro Aldo M, Tucci Alessandra, Rossi Giuseppe

Abstract excerpt

Therapy-related myeloid neoplasm (t-MN) is a threatening complication of autologous stem cell transplantation (ASCT). Detecting clonal hematopoiesis (CH) mutations in cryopreserved cells before ASCT has been associated with a higher risk of t-MN, but the evolution of molecular abnormalities from pre-ASCT to t-MN, within the same patient, remains to be elucidated. We evaluated the mutational profile of 19...

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PMID: 35380239
DOI: 10.1007/s00277-022-04806-x

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