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Article

Therapy-related myeloid neoplasms: when genetics and environment collide.

Nature reviews. Cancer - 24 Aug 2017

McNerney Megan E, Godley Lucy A, Le Beau Michelle M

Abstract excerpt

Therapy-related myeloid neoplasms (t-MN) arise as a late effect of chemotherapy and/or radiation administered for a primary condition, typically a malignant disease, solid organ transplant or autoimmune disease. Survival is measured in months, not years, making t-MN one of the most aggressive and lethal cancers. In this Review, we discuss recent developments that reframe our understanding of the genetic and...

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Antineoplastic Agents, Alkylating
Bone Marrow Cells
Chromosomes, Human, Pair 5
Chromosomes, Human, Pair 7
Clone Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Myelodysplastic Syndromes

Neoplasms, Second Primary

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PMID: 28835720
DOI: 10.1038/nrc.2017.60
PMCID: PMC5946699

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