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Article

What's new in the pathogenesis and treatment of therapy-related myeloid neoplasms.

Blood - 2 Sept 2021

Voso Maria Teresa, Falconi Giulia, Fabiani Emiliano

Abstract excerpt

Therapy-related myeloid neoplasms (t-MNs) include diseases onsetting in patients treated with chemo- and/or radiotherapy for a primary cancer, or an autoimmune disorder. Genomic variants, in particular, in familial cancer genes, may play a predisposing role. Recent advances in deep sequencing techniques have shed light on the pathogenesis of t-MNs, identifying clonal hematopoiesis of indeterminate potential...

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PMID: 33876223
DOI: 10.1182/blood.2021010764

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