The association of APOE genotype and cognitive decline in interaction with risk factors in a 65-69 year old community sample.

doi:10.1186/1471-2318-8-14

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Article

The association of APOE genotype and cognitive decline in interaction with risk factors in a 65-69 year old community sample.

BMC geriatrics - 14 Jul 2008

Christensen Helen, Batterham Philip J, Mackinnon Andrew J, Jorm Anthony F, Mack Holly A, Mather Karen A, Anstey Kaarin J, Sachdev Perminder S, Easteal Simon

Abstract excerpt

BACKGROUND: While the evidence of an association between the apolipoprotein E (APOE) *E4 allele and Alzheimer's disease is very strong, the effect of the *E4 allele on cognitive decline in the general population is more equivocal. A cross-sectional study on the lifespan effects of the *E4 allele 1 failed to find any effect of the *E4 allele on cognitive performance at ages 20-24, 40-44 or 60-64 years. METHODS: In...

Topics

Adult
Aged
Alzheimer Disease
Apolipoproteins E
Australia
Cognition Disorders
Cross-Sectional Studies
Female
Follow-Up Studies
Genotype
Geriatric Assessment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Heterozygote

Humans

Intelligence Tests

Male

Middle Aged

Risk Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 18620605
DOI: 10.1186/1471-2318-8-14
PMCID: PMC2488328

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-18620605-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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