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Longitudinal change in working memory as a function of <scp>APOE</scp> genotype in midlife and old age

22 May 2014

Abstract excerpt

Previous investigations into whether the APOE-ε4 allele exerts cognitive effects at midlife have been inconclusive. We have advanced a "cognitive phenotype" hypothesis arguing that the ε4 allele of the apolipoprotein E gene (APOE) is associated with lower efficiency of neuronal plasticity thereby resulting in poorer cognitive performance independently of the pathology of Alzheimer's disease (Greenwood et al., )....

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PMID: 24853824
DOI: 10.1111/sjop.12123

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