Article
Matrix stiffening promotes a tumor vasculature phenotype.
Proceedings of the National Academy of Sciences of the United States of America - 17 Jan 2017
Bordeleau Francois, Mason Brooke N, Lollis Emmanuel Macklin, Mazzola Michael, Zanotelli Matthew R, Somasegar Sahana, Califano Joseph P, Montague Christine, LaValley Danielle J, Huynh John, Mencia-Trinchant Nuria, Negrón Abril Yashira L, Hassane Duane C, Bonassar Lawrence J, Butcher Jonathan T, Weiss Robert S, Reinhart-King Cynthia A
Abstract excerpt
Tumor microvasculature tends to be malformed, more permeable, and more tortuous than vessels in healthy tissue, effects that have been largely attributed to up-regulated VEGF expression. However, tumor tissue tends to stiffen during solid tumor progression, and tissue stiffness is known to alter cell behaviors including proliferation, migration, and cell-cell adhesion, which are all requisite for angiogenesis....
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