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Engineering the Extracellular Matrix to Model the Evolving Tumor Microenvironment

26 Oct 2020

Abstract excerpt

Clinical evidence supports a role for the extracellular matrix (ECM) in cancer risk and prognosis across multiple tumor types, and numerous studies have demonstrated that individual ECM components impact key hallmarks of tumor progression (e.g., proliferation, migration, angiogenesis). However, the ECM is a complex network of fibrillar proteins, glycoproteins, and proteoglycans that undergoes dramatic changes in...

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PMID: 33225247
DOI: 10.1016/j.isci.2020.101742

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