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Article

Tensional homeostasis and the malignant phenotype.

Cancer cell - 1 Sept 2005

Paszek Matthew J, Zahir Nastaran, Johnson Kandice R, Lakins Johnathon N, Rozenberg Gabriela I, Gefen Amit, Reinhart-King Cynthia A, Margulies Susan S, Dembo Micah, Boettiger David, Hammer Daniel A, Weaver Valerie M

Abstract excerpt

Tumors are stiffer than normal tissue, and tumors have altered integrins. Because integrins are mechanotransducers that regulate cell fate, we asked whether tissue stiffness could promote malignant behavior by modulating integrins. We found that tumors are rigid because they have a stiff stroma and elevated Rho-dependent cytoskeletal tension that drives focal adhesions, disrupts adherens junctions, perturbs...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16169468
DOI: 10.1016/j.ccr.2005.08.010

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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