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Article

3D collagen architecture induces a conserved migratory and transcriptional response linked to vasculogenic mimicry

15 Nov 2017

Abstract excerpt

The topographical organization of collagen within the tumor microenvironment has been implicated in modulating cancer cell migration and independently predicts progression to metastasis. Here, we show that collagen matrices with small pores and short fibers, but not Matrigel, trigger a conserved transcriptional response and subsequent motility switch in cancer cells resulting in the formation of multicellular...

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PMID: 29162797
DOI: 10.1038/s41467-017-01556-7

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