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Article

Reduced brain activation during inhibitory control in children with COMT Val/Val genotype.

Brain and behavior - 1 Dec 2016

Cope Lora M, Hardee Jillian E, Soules Mary E, Burmeister Margit, Zucker Robert A, Heitzeg Mary M

Abstract excerpt

INTRODUCTION: Behavioral undercontrol is a well-established risk factor for substance use disorder, identifiable at an early age well before the onset of substance use. However, the biological mechanistic structure underlying the behavioral undercontrol/substance use relationship is not well understood. The enzyme catechol O-methyltransferase (COMT) catabolizes dopamine and norepinephrine in the prefrontal cortex...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Source

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Identifiers

PMID: 28032000
DOI: 10.1002/brb3.577
PMCID: PMC5167006

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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