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Article

Impact of the COMT Val108/158 Met and DAT genotypes on prefrontal function in healthy subjects.

NeuroImage - 1 Oct 2007

Caldú Xavier, Vendrell Pere, Bartrés-Faz David, Clemente Inmaculada, Bargalló Núria, Jurado María Angeles, Serra-Grabulosa Josep Maria, Junqué Carme

Abstract excerpt

Two limiting factors of dopamine activity are the catechol-o-methyltransferase (COMT) and the dopamine transporter (DAT), which terminate dopamine activity by degradation and uptake, respectively. Genetic variants of COMT and DAT have been related to the enzymatic activity and protein availability, respectively. The Met allele of the COMT Val108/158 Met polymorphism has been associated to lower enzymatic activity...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17689985
DOI: 10.1016/j.neuroimage.2007.06.021

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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