The divergent impact of COMT Val158Met on executive function in children with and without attention-deficit/hyperactivity disorder.

doi:10.1111/gbb.12270

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Article

The divergent impact of COMT Val158Met on executive function in children with and without attention-deficit/hyperactivity disorder.

Genes, brain, and behavior - 1 Feb 2016

Jin J, Liu L, Gao Q, Chan R C K, Li H, Chen Y, Wang Y, Qian Q

Abstract excerpt

Children with attention-deficit/hyperactivity disorder (ADHD) usually display deficits in executive function (EF), which are primarily mediated by prefrontal cortex (PFC). The functional polymorphism of catechol-O-methyltransferase (COMT), Val158Met (rs4680), leads to observed polymorphic differences in the degradation of dopamine within PFC. This study aimed to explore the effect of rs4680 on EF using...

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Identifiers

PMID: 26560848
DOI: 10.1111/gbb.12270

Genes

COMT

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