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Article

Variations in the catechol O-methyltransferase polymorphism and prefrontally guided behaviors in adolescents.

Biological psychiatry - 1 Mar 2007

Wahlstrom Dustin, White Tonya, Hooper Catalina J, Vrshek-Schallhorn Suzanne, Oetting William S, Brott Marcia J, Luciana Monica

Abstract excerpt

BACKGROUND: The catechol-O-methyltransferase (COMT) gene codes for an enzyme that degrades prefrontal cortex (PFC) synaptic dopamine. Of two identified alleles (Met and Val), the Met allele results in COMT activity that is up to 4 times less pronounced than that conferred by the Val allele, resulting in greater PFC dopamine concentrations. Met-Met homozygotes perform better than individuals who possess the Val...

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Source

Identifiers

PMID: 17014828
DOI: 10.1016/j.biopsych.2006.05.045

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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