Article
A genotypic method for determining HIV-2 coreceptor usage enables epidemiological studies and clinical decision support.
Retrovirology - 20 Dec 2016
Döring Matthias, Borrego Pedro, Büch Joachim, Martins Andreia, Friedrich Georg, Camacho Ricardo Jorge, Eberle Josef, Kaiser Rolf, Lengauer Thomas, Taveira Nuno, Pfeifer Nico
Abstract excerpt
BACKGROUND: CCR5-coreceptor antagonists can be used for treating HIV-2 infected individuals. Before initiating treatment with coreceptor antagonists, viral coreceptor usage should be determined to ensure that the virus can use only the CCR5 coreceptor (R5) and cannot evade the drug by using the CXCR4 coreceptor (X4-capable). However, until now, no online tool for the genotypic identification of HIV-2 coreceptor...
Topics
- CCR5 Receptor Antagonists
- Decision Support Systems, Clinical
- Genotype
- Genotyping Techniques
- HIV Envelope Protein gp120
- HIV Infections
- HIV-2
- Humans
- Internet
- Peptide Fragments
- Receptors, CCR5
- Receptors, CXCR4
- Support Vector Machine