Article
Appraising the performance of genotyping tools in the prediction of coreceptor tropism in HIV-1 subtype C viruses.
BMC infectious diseases - 2 Sept 2012
Crous Saleema, Shrestha Ram Krishna, Travers Simon A
Abstract excerpt
BACKGROUND: In human immunodeficiency virus type 1 (HIV-1) infection, transmitted viruses generally use the CCR5 chemokine receptor as a coreceptor for host cell entry. In more than 50% of subtype B infections, a switch in coreceptor tropism from CCR5- to CXCR4-use occurs during disease progression. Phenotypic or genotypic approaches can be used to test for the presence of CXCR4-using viral variants in an...
Topics
- Genotype
- HIV Envelope Protein gp120
- HIV-1
- Humans
- Receptors, HIV
- Viral Tropism