Article
Detection of inferred CCR5- and CXCR4-using HIV-1 variants and evolutionary intermediates using ultra-deep pyrosequencing.
PLoS pathogens - 1 Jun 2011
Bunnik Evelien M, Swenson Luke C, Edo-Matas Diana, Huang Wei, Dong Winnie, Frantzell Arne, Petropoulos Christos J, Coakley Eoin, Schuitemaker Hanneke, Harrigan P Richard, van 't Wout Angélique B
Abstract excerpt
The emergence of CXCR4-using human immunodeficiency virus type 1 (HIV-1) variants is associated with accelerated disease progression. CXCR4-using variants are believed to evolve from CCR5-using variants, but due to the extremely low frequency at which transitional intermediate variants are often present, the kinetics and mutational pathways involved in this process have been difficult to study and are therefore...
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