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Correlation of coreceptor usage and disease progression

7 Aug 2012

Abstract excerpt

PURPOSE OF REVIEW: Primary HIV-1 infection is usually initiated by viruses with an exclusive affinity for the C-C chemokine receptor type 5 (CCR5) coreceptor. Viral variants that are also able to bind the C-X-C chemokine receptor type 4 (CXCR4) coreceptor arise during the course of the disease in about 50% of the infected individuals and their emergence is associated with a faster disease progression. In this...

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PMID: 22871636
DOI: 10.1097/coh.0b013e328356f6f2

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