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Article

Improved prediction of HIV‐1 coreceptor usage with sequence information from the second hypervariable loop of gp120.

The Journal of infectious diseases - 1 Nov 2010

Thielen Alexander, Sichtig Nadine, Kaiser Rolf, Lam Jeffrey, Harrigan P Richard, Lengauer Thomas

Abstract excerpt

BACKGROUND: Human immunodeficiency virus type 1 (HIV‐1) uses the CD4 receptor and a coreceptor to gain cell entry. Coreceptor usage is mainly determined by the V3 loop of gp120. Therefore, coreceptor usage is currently inferred from the genotype on the basis of V3 alone. However, several mutations outside V3 have been repeatedly reported to influence coreceptor usage. In this study, the impact of the V2 loop on...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20874088
DOI: 10.1086/656600

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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