Article
Predicting HIV coreceptor usage on the basis of genetic and clinical covariates.
Antiviral therapy - 1 Jan 2007
Sing Tobias, Low Andrew J, Beerenwinkel Niko, Sander Oliver, Cheung Peter K, Domingues Francisco S, Büch Joachim, Däumer Martin, Kaiser Rolf, Lengauer Thomas, Harrigan P Richard
Abstract excerpt
BACKGROUND: We compared several statistical learning methods for the prediction of HIV coreceptor use from clonal HIV third hypervariable (V3) loop sequences, and evaluated and improved their effectiveness on clinical samples. METHODS: Support vector machines (SVM), artificial neural networks, position-specific scoring matrices (PSSM) and mixtures of localized rules were estimated and tested using 10x ten-fold...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.