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Article

Current V3 genotyping algorithms are inadequate for predicting X4 co-receptor usage in clinical isolates.

AIDS (London, England) - 12 Sept 2007

Low Andrew J, Dong Winnie, Chan Dennison, Sing Tobias, Swanstrom Ronald, Jensen Mark, Pillai Satish, Good Benjamin, Harrigan P Richard

Abstract excerpt

OBJECTIVE: Integrating CCR5 antagonists into clinical practice would benefit from accurate assays of co-receptor usage (CCR5 versus CXCR4) with fast turnaround and low cost. DESIGN: Published HIV V3-loop based predictors of co-receptor usage were compared with actual phenotypic tropism results in a large cohort of antiretroviral naive individuals to determine accuracy on clinical samples and identify areas for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17721088
DOI: 10.1097/QAD.0b013e3282ef81ea

Genes

CXCR4
CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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